Cardiac sympathetic denervation correlates with clinical and pathologic stages of Parkinson's disease
Identifieur interne : 002957 ( Main/Exploration ); précédent : 002956; suivant : 002958Cardiac sympathetic denervation correlates with clinical and pathologic stages of Parkinson's disease
Auteurs : Hiroshige Fujishiro [États-Unis] ; Roberta Frigerio [États-Unis] ; Melinda Burnett [États-Unis] ; Kevin J. Klos [États-Unis] ; Keith A. Josephs [États-Unis] ; Anthony Delledonne [États-Unis] ; Joseph E. Parisi [États-Unis] ; J. Eric Ahlskog [États-Unis] ; Dennis W. Dickson [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2008-06-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Brain (pathology), Clinical stage, Denervation, Disease Progression, Female, Heart (innervation), Humans, Hypotension, Orthostatic (diagnosis), Hypotension, Orthostatic (pathology), Lewy Bodies (pathology), Male, Nerve Degeneration (pathology), Nerve Fibers (pathology), Nervous system diseases, Neurites (pathology), Parkinson Disease (diagnosis), Parkinson Disease (pathology), Parkinson disease, Parkinsons, Pericardium (innervation), Pericardium (pathology), Spinal Cord (pathology), Sympathetic Nervous System (pathology), Tyrosine 3-Monooxygenase (analysis), Tyrosine 3-monooxygenase, alpha-Synuclein (analysis), cardiac, presymptomatic, tyrosine hydroxylase, α‐synuclein.
- MESH :
- chemical , analysis : Tyrosine 3-Monooxygenase, alpha-Synuclein.
- diagnosis : Hypotension, Orthostatic, Parkinson Disease.
- innervation : Heart, Pericardium.
- pathology : Brain, Hypotension, Orthostatic, Lewy Bodies, Nerve Degeneration, Nerve Fibers, Neurites, Parkinson Disease, Pericardium, Spinal Cord, Sympathetic Nervous System.
- Aged, Aged, 80 and over, Disease Progression, Female, Humans, Male.
Abstract
Attention has been drawn to cardiac sympathetic denervation in Parkinson's disease (PD) based on clinical studies using [123I] metaiodobenzylguanidine scintigraphy; however, the histologic correlates and time course of cardiac sympathetic denervation are poorly understood. To address these issues, we used tyrosine hydroxylase (TH) immunohistochemistry to detect cardiac sympathetic nerve fibers in the epicardium of 4 normal controls, 11 cases with incidental Lewy bodies (iLBs), and 14 cases of PD. Cardiac sympathetic innervation was significantly less in PD than in normal controls and cases with iLBs (P < 0.05). There was also a decrease in TH‐immunoreactive fibers in iLB cases compared to normal controls (P < 0.01). TH‐immunoreactive fibers correlated with the PD stage (r = −0.75, P < 0.001), as well as with Hoehn & Yahr clinical stage (r = −0.61, P < 0.001), and disease duration (r = −0.63, P < 0.001). Immunohistochemistry for α‐synuclein showed neurites in epicardium in PD and iLB cases, but not in normal controls. The density of α‐synuclein neurites correlated with Braak PD stage (r = 0.38, P < 0.05), Hoehn & Yahr clinical stage (r = 0.44, P < 0.05), and disease duration (r = 0.42, P < 0.05). This study demonstrates that cardiac sympathetic degeneration and α‐synuclein pathology is present in presymptomatic phase of PD, and that both increase with disease duration and severity. © 2008 Movement Disorder Society.
Url:
DOI: 10.1002/mds.21989
Affiliations:
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Klos</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Oklahoma</region></placeName><wicri:cityArea>Neurological Associates of Tulsa, Tulsa</wicri:cityArea></affiliation></author><author><name sortKey="Josephs, Keith A" sort="Josephs, Keith A" uniqKey="Josephs K" first="Keith A." last="Josephs">Keith A. Josephs</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Department of Neurology, Mayo Clinic, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Delledonne, Anthony" sort="Delledonne, Anthony" uniqKey="Delledonne A" first="Anthony" last="Delledonne">Anthony Delledonne</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Department of Pathology (Neuropathology), Mayo Clinic, Jacksonville</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Department of Neuroscience, Mayo Clinic, Jacksonville</wicri:cityArea></affiliation></author><author><name sortKey="Parisi, Joseph E" sort="Parisi, Joseph E" uniqKey="Parisi J" first="Joseph E." last="Parisi">Joseph E. 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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2008-06-15">2008-06-15</date><biblScope unit="vol">23</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="1085">1085</biblScope><biblScope unit="page" to="1092">1092</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">B2D178713218F90FD26FD418975AA3283957D11C</idno><idno type="DOI">10.1002/mds.21989</idno><idno type="ArticleID">MDS21989</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Brain (pathology)</term><term>Clinical stage</term><term>Denervation</term><term>Disease Progression</term><term>Female</term><term>Heart (innervation)</term><term>Humans</term><term>Hypotension, Orthostatic (diagnosis)</term><term>Hypotension, Orthostatic (pathology)</term><term>Lewy Bodies (pathology)</term><term>Male</term><term>Nerve Degeneration (pathology)</term><term>Nerve Fibers (pathology)</term><term>Nervous system diseases</term><term>Neurites (pathology)</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (pathology)</term><term>Parkinson disease</term><term>Parkinsons</term><term>Pericardium (innervation)</term><term>Pericardium (pathology)</term><term>Spinal Cord (pathology)</term><term>Sympathetic Nervous System (pathology)</term><term>Tyrosine 3-Monooxygenase (analysis)</term><term>Tyrosine 3-monooxygenase</term><term>alpha-Synuclein (analysis)</term><term>cardiac</term><term>presymptomatic</term><term>tyrosine hydroxylase</term><term>α‐synuclein</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Tyrosine 3-Monooxygenase</term><term>alpha-Synuclein</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Hypotension, Orthostatic</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="innervation" xml:lang="en"><term>Heart</term><term>Pericardium</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term><term>Hypotension, Orthostatic</term><term>Lewy Bodies</term><term>Nerve Degeneration</term><term>Nerve Fibers</term><term>Neurites</term><term>Parkinson Disease</term><term>Pericardium</term><term>Spinal Cord</term><term>Sympathetic Nervous System</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Disease Progression</term><term>Female</term><term>Humans</term><term>Male</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Enervation</term><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Stade clinique</term><term>Tyrosine 3-monooxygenase</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Attention has been drawn to cardiac sympathetic denervation in Parkinson's disease (PD) based on clinical studies using [123I] metaiodobenzylguanidine scintigraphy; however, the histologic correlates and time course of cardiac sympathetic denervation are poorly understood. To address these issues, we used tyrosine hydroxylase (TH) immunohistochemistry to detect cardiac sympathetic nerve fibers in the epicardium of 4 normal controls, 11 cases with incidental Lewy bodies (iLBs), and 14 cases of PD. Cardiac sympathetic innervation was significantly less in PD than in normal controls and cases with iLBs (P < 0.05). There was also a decrease in TH‐immunoreactive fibers in iLB cases compared to normal controls (P < 0.01). TH‐immunoreactive fibers correlated with the PD stage (r = −0.75, P < 0.001), as well as with Hoehn & Yahr clinical stage (r = −0.61, P < 0.001), and disease duration (r = −0.63, P < 0.001). Immunohistochemistry for α‐synuclein showed neurites in epicardium in PD and iLB cases, but not in normal controls. The density of α‐synuclein neurites correlated with Braak PD stage (r = 0.38, P < 0.05), Hoehn & Yahr clinical stage (r = 0.44, P < 0.05), and disease duration (r = 0.42, P < 0.05). This study demonstrates that cardiac sympathetic degeneration and α‐synuclein pathology is present in presymptomatic phase of PD, and that both increase with disease duration and severity. © 2008 Movement Disorder Society.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Floride</li><li>Minnesota</li><li>Oklahoma</li></region></list><tree><country name="États-Unis"><region name="Floride"><name sortKey="Fujishiro, Hiroshige" sort="Fujishiro, Hiroshige" uniqKey="Fujishiro H" first="Hiroshige" last="Fujishiro">Hiroshige Fujishiro</name></region><name sortKey="Ahlskog, J Eric" sort="Ahlskog, J Eric" uniqKey="Ahlskog J" first="J. Eric" last="Ahlskog">J. Eric Ahlskog</name><name sortKey="Burnett, Melinda" sort="Burnett, Melinda" uniqKey="Burnett M" first="Melinda" last="Burnett">Melinda Burnett</name><name sortKey="Delledonne, Anthony" sort="Delledonne, Anthony" uniqKey="Delledonne A" first="Anthony" last="Delledonne">Anthony Delledonne</name><name sortKey="Delledonne, Anthony" sort="Delledonne, Anthony" uniqKey="Delledonne A" first="Anthony" last="Delledonne">Anthony Delledonne</name><name sortKey="Dickson, Dennis W" sort="Dickson, Dennis W" uniqKey="Dickson D" first="Dennis W." last="Dickson">Dennis W. Dickson</name><name sortKey="Dickson, Dennis W" sort="Dickson, Dennis W" uniqKey="Dickson D" first="Dennis W." last="Dickson">Dennis W. Dickson</name><name sortKey="Frigerio, Roberta" sort="Frigerio, Roberta" uniqKey="Frigerio R" first="Roberta" last="Frigerio">Roberta Frigerio</name><name sortKey="Fujishiro, Hiroshige" sort="Fujishiro, Hiroshige" uniqKey="Fujishiro H" first="Hiroshige" last="Fujishiro">Hiroshige Fujishiro</name><name sortKey="Josephs, Keith A" sort="Josephs, Keith A" uniqKey="Josephs K" first="Keith A." last="Josephs">Keith A. Josephs</name><name sortKey="Klos, Kevin J" sort="Klos, Kevin J" uniqKey="Klos K" first="Kevin J." last="Klos">Kevin J. Klos</name><name sortKey="Parisi, Joseph E" sort="Parisi, Joseph E" uniqKey="Parisi J" first="Joseph E." last="Parisi">Joseph E. Parisi</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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